What is the role of IV infusion of lipid emulsions in the treatment of local anesthetic toxicity?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Current guidelines recommend the intravenous (IV) infusion of lipid emulsion to reverse the cardiac and neurologic effects of local anesthetic toxicity. [2, 8]  Although no blinded studies have been conducted in humans, a systemic review and meta-analysis has confirmed the efficacy of lipid emulsion therapy. [9] Case reports support the early use of lipid emulsion at the first sign of arrhythmia, prolonged seizure activity, or rapid progression of toxic manifestations in patients with suspected local anesthetic toxicity. [1]


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