What is the typical progression for local anesthetic toxicity?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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If oxygenation, ventilation, and cardiac output are maintained, patients usually have a full recovery without sequelae. Without treatment, local anesthetic toxicity can result in seizures, respiratory depression or arrest, hypotension, cardiovascular collapse or cardiac arrest, and death. According to the AAPCC National Poison Data System 2019 Annual Report, 319 of the lidocaine exposures had no negative outcome; 244 exposures resulted in a minor outcome;96, in a moderate outcome; and 24, in a major outcome; 3 deaths were reported. [5]

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