What are risk factors for local anesthetic toxicity?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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In addition to high doses, high injection rates also increase the risk of adverse reactions to local anesthetics. Patient factors that increase risk include the following:

  • Renal or hepatic compromise

  • Metabolic or respiratory acidosis

  • Preexisting heart block or heart conditions

  • Pregnancy

  • Extremes of age

  • Hypoxia

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