What is the minimum doses of local anesthetic that can cause toxicity?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Local anesthetic toxicity can occur because of inadvertent intravascular injection or dosing error. Intravascular injection can cause toxicity even if the anesthetic was administered within the recommended dose range.

The minimum doses of anesthetics in which adverse reactions have occurred are listed in Table 3, below.

Table 3. Minimum Intravenous Toxic Dose of Local Anesthetic in Humans [3] (Open Table in a new window)

Agent

Minimum Toxic Dose (mg/kg)

Procaine

19.2

Tetracaine

2.5

Chloroprocaine

22.8

Lidocaine

6.4

Mepivacaine

9.8

Bupivacaine

1.6

Etidocaine

3.4


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