How are toxicity manifestations of local anesthetic agents categorized?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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Manifestations of local anesthetic toxicity typically appear 1 to 5 minutes after the injection, but onset may range from 30 seconds to as long as 60 minutes. [1] Toxicity manifestations can be categorized as follows:

  • CNS

  • Cardiovascular

  • Hematologic

  • Allergic

  • Local tissue

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