How is the incidence of seromas due to a modified radical mastectomy reduced?

Updated: Jun 18, 2021
  • Author: Nafisa K Kuwajerwala, MD; Chief Editor: Erik D Schraga, MD  more...
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A randomized, controlled trial by Archana et al indicated that compared with electrocautery, the use of the harmonic scalpel in modified radical mastectomy significantly reduces the incidence of seromas found on initial postoperative follow-up (34.3% vs 21.7%, respectively), as well as the mean total seroma drainage volume (937.5 mL vs 470 mL, respectively). [13]  A retrospective study by van Bastelaar et al indicated that following either a mastectomy and sentinel node biopsy or a modified radical mastectomy, flap fixation using sutures or ARTISS fibrin sealant lessened the need for postoperative seroma aspiration compared with a drain-only approach. [14]

Similarly, in a study of patients who underwent mastectomy, including modified radical mastectomy, de Rooij et al found that flap fixation using sutures significantly reduced postoperative seroma aspiration compared with conventional wound closure. The investigators reported that 7.3% of suture fixation patients underwent aspiration, compared with 17.5% of those treated with conventional closure. [15]

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