Which conditions should be included in the differential diagnoses of esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Always consider the possibility of a systemic illness causing the esophageal manifestations (eg, acquired immunodeficiency syndrome [AIDS], scleroderma, systemic lupus erythematosus (SLE), pemphigus). Always consider cardiac causes of chest discomfort and treat appropriately. If the diagnosis is unclear, admission for further evaluation is suggested. Do not misdiagnose cardiac chest pain as esophageal pain. Pain can be similar, particularly in elderly patients and women.

See Pediatric Esophagitis for complete information on this topic.

Conditions that may mimic symptoms of esophagitis include the following:

  • Coronary artery disease
  • Pericarditis
  • Aortic aneurysm
  • Nonulcer reflux disease
  • Functional dyspepsia
  • Stricture

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