Which systemic illnesses are associated with esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Systemic illnesses that can result in esophagitis include the following:

  • Skin disorders, including epidermolysis bullosa, pemphigus vulgaris, bullous pemphigoid, cicatricial pemphigoid, drug-induced skin disorders (eg, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), and others (eg, lichen planus, psoriasis, acanthosis nigricans, leukoplakia)
  • Eosinophilic esophagitis
  • Chronic granulomatous disease
  • Metastatic cancer
  • Collagen vascular disease
  • Motility disorders of the esophagus lead to poor acid clearing, with resulting epithelial damage (ie, gastroesophageal reflux disease in scleroderma)

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