Which factors and conditions increase the risk of reflux esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Factors or conditions that may increase the risk of reflux esophagitis include the following:

  • Pregnancy
  • Obesity
  • Scleroderma
  • Smoking
  • Alcohol, coffee, chocolate, fatty or spicy foods
  • Certain medications (eg, beta blockers, nonsteroidal anti-inflammatory drugs [NSAIDs], theophylline, nitrates, alendronate, calcium-channel blockers)
  • Mental retardation requiring institutionalization
  • Spinal cord injury
  • Immunocompromised state
  • Radiation therapy for chest tumors

Helicobacter pylori eradication therapy has been inversely related to reflux esophagitis; it is postulated that the ammonia (alkaline) produced by H pylori reduces the acidity of the stomach and, hence, protects the esophagus from acid spillage.

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