What is the role of antibody screening in pretransfusion compatibility testing?

Updated: Jun 24, 2019
  • Author: Ashok Tholpady, MD, MSc; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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Before a patient is transfused with a unit of blood, pretransfusion compatibility testing must be performed. It includes a type, screen, and crossmatch. Typing determines the ABO antigens on the recipient's RBCs and antibodies present in the patient's plasma or serum. Crossmatching is the final step in compatibility testing, in which RBCs from a donor unit is mixed with patient sera. If agglutination does not occur, then blood from the donor unit can be released to the patient. The occurrence of agglutination would require further testing.

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