What is the prophylaxis regimen for endocarditis in patients allergic to penicillin?

Updated: Feb 05, 2018
  • Author: Mary L Windle, PharmD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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  • Adult dose: 600 mg PO
  • Pediatric dose: 20 mg/kg PO; not to exceed 600 mg/dose

Cephalexin or other first- or second-generation oral cephalosporin in equivalent dose (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)

  • Adult dose: 2 g PO
  • Pediatric dose: 50 mg/kg PO; not to exceed 2 g/dose

Azithromycin or clarithromycin

  • Adult dose: 500 mg PO
  • Pediatric dose: 15 mg/kg PO; not to exceed 500 mg/dose

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