According to the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, what does acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) encompass?

Updated: Jul 28, 2020
  • Author: Angie Duong, MD; Chief Editor: Aliyah R Sohani, MD  more...
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The revised 4th edition (2016/2017 update) of the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues has focused increased attention on genetic abnormalities to characterize and subclassify acute myeloid leukemia (AML), including AML with myelodysplasia-related changes (AML-MRC). [1, 2]

AML-MRC encompasses the following:

  • AML arising in myelodysplastic syndrome (MDS) or in myelodysplastic/myeloproliferative neoplasm (MDS/MPN)
  • AML with MDS-related cytogenetic abnormalities
  • AML with multilineage dysplasia

This category of AML primarily occurs in elderly patients; it is rare in children. AML-MRC represents 25-35% of AML cases. [3, 4, 5, 6]


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