What is the role of cardiac sarcoidosis in the etiology of first-degree atrioventricular (AV) block?

Updated: Jan 06, 2020
  • Author: Jamshid Alaeddini, MD, FACC, FHRS; Chief Editor: Jose M Dizon, MD  more...
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Answer

Infiltrative disease, such as sarcoidosis, may involve the cardiac conduction system as well as other organ systems. Cardiac sarcoidosis may precede, follow, or occur concurrently with involvement of the lungs or other organs. Symptomatic cardiac involvement is estimated to occur in 2–7% of patients with sarcoidosis. Conduction abnormalities may range from first-degree heart block to complete heart block (25-30%). [10]  Sustained or nonsustained ventricular tachycardia is also common in patients with cardiac sarcoidosis and, along with complete heart block, are the most common causes of sudden cardiac death in patients with cardiac sarcoidosis.


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