How does Lenègre disease cause first-degree atrioventricular (AV) block?

Updated: Jan 06, 2020
  • Author: Jamshid Alaeddini, MD, FACC, FHRS; Chief Editor: Jose M Dizon, MD  more...
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Answer

Lenègre disease is an idiopathic, fibrotic degenerative disease restricted to the His-Purkinje system. It is caused by fibrocalcareous changes in the mitral annulus, membranous septum, aortic valve, and crest of the ventricular septum. These degenerative and sclerotic changes are not attributed to inflammatory or ischemic involvement of adjacent myocardium. Lenègre disease involves the middle and distal portions of both bundle branches and affects a younger population than Lev disease does.


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