What are the ultrastructural microscopic findings characteristic of clear cell renal cell carcinoma (CCRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Ultrastructurally, CCRCC shows tubular differentiation, with tumor cells clustered around microlumens and separated from the stroma by a well-defined basal lamina. Distinctive features include long microvilli typical of the brush border seen in renal proximal tubules and abundant lipid vacuoles and glycogen deposits.

Other organelles such as Golgi bodies and rough endoplasmic reticulum tend to be absent or sparse and may be pushed to the cell periphery by accumulations of lipid and glycogen. [43] Cells with eosinophilic granular cytoplasm still display high levels of lipid and glycogen but also contain increased numbers of mitochondria, which tend to be large, pleomorphic, and haphazardly distributed through the cytoplasm. [59]


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