What are the characteristics of rhabdoid differentiation in clear cell renal cell carcinoma (CCRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Rhabdoid differentiation occurs in 3-5% of RCCs, most commonly in CCRCC, and is identified as focal to extensive regions of large, high-grade malignant cells with abundant eosinophilic cytoplasm, irregular eccentric nuclei, and large globular eosinophilic intracytoplasmic inclusions that stain strongly for vimentin. [51, 52, 53, 54] Occasionally, both forms of differentiation may coexist within a tumor.


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