What is the prevalence of cell renal cell carcinoma (CCRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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The incidence of renal cell carcinoma (RCC) has been rising steadily in Europe and the United States for the past 3 decades, with a particular rise in the proportion of small, asymptomatic tumors detected incidentally via abdominal imaging.

Evidence of geographic variation exists, with the highest incidences occurring in northern Europe and North America and the lowest occurring in Asia and Africa. Higher rates are reported for men than women (the male-to-female ratios range between 1.5:1 and 2:1), for black versus white Americans, and for urban compared with rural populations. [2, 3, 4] These trends mainly reflect the incidence of clear cell renal cell carcinoma (CCRCC), which is the most common histologic variant, accounting for 75-88% of RCCs in contemporary surgical series. [5, 6]

The average age at diagnosis of CCRCC is 60-64 years. [5, 7, 8] However, 7% of sporadic CCRCC is diagnosed in patients younger than 40 years, [9] and rare cases have been reported in patients aged 14-18 years without evidence of familial disorders. [10] Some tumors previously diagnosed as CCRCC in younger patients may in fact represent the Xp11 translocation tumor type, which has recently been analyzed. [11]

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