Which clinical history findings are characteristic of translocation-associated renal cell carcinomas (RCCs)?

Updated: May 17, 2017
  • Author: Angela J Wu, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

A significant proportion (17-25%) of patients with Xp11.2 translocation-associated RCCs and at least 1 patient with t(6;11) translocation-associated RCC had a history of chemotherapy. [1, 2, 4, 11] In rare instances, Xp11.2 translocation-associated RCC is associated with another condition, such as sickle cell hemoglobinopathy trait, hemihypertrophy of the face, Saethre-Chotzen syndrome, cryptorchidism, or coccygeal teratoma. [1, 3, 4, 7, 8]


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