What is the role of hypertrophic cardiomyopathy in the etiology of ventricular tachycardia (VT)?

Updated: Dec 05, 2017
  • Author: Steven J Compton, MD, FACC, FACP, FHRS; Chief Editor: Jeffrey N Rottman, MD  more...
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Hypertrophic cardiomyopathy is usually inherited in an autosomal dominant fashion with incomplete penetrance. Mutations in four genes that encode sarcomeric proteins—TNNT2, MYBPC3, MYH7, ­and TNNI3—account for approximately 90% of cases. [27] Most people with symptomatic hypertrophic cardiomyopathy will experience them at rest. Less often, a person with this disorder will experience an initial episode of VT or VF with significant exertion.

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