What is the role of surgery in the treatment of ventricular premature complexes (VPCs)?

Updated: Nov 26, 2016
  • Author: Jatin Dave, MD, MPH; Chief Editor: Jose M Dizon, MD  more...
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Patients deemed to be at high risk of sudden cardiac death may benefit from implantable cardioverter defibrillator (ICD) implantation.

Catheter-based renal sympathetic denervation (RSD) may have a role in reducing the arrhythmic burden of ventricular arrhythmias, including PVCs, that are refractory to pharmacotherapy. [24] In a preliminary study of 34 patients with PVCs and structurally normal hearts (20 underwent ablation RSD, 14 served as controls), investigators noted that at 3-, 6- (first month after RSD, without drugs), 7-, and 12-month (sixth month after RSD, without drugs) follow-up, those treated with RSD had significantly reduced numbers of polymorphic PVCs compared to baseline. Although neither patient group showed any changes in mean 24-hour ambulatory blood pressure monitoring (ABPM) and renal function at 12 months, the control group demonstrated a decrease in 24-hour Holter mean heart rate. The change in number of polymorphic PVCs at 6 months post RSD was significantly associated with the total number of RSD ablated sites. [24]

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