What causes ventricular premature complexes (VPCs)?

Updated: Nov 26, 2016
  • Author: Jatin Dave, MD, MPH; Chief Editor: Jose M Dizon, MD  more...
  • Print

Cardiac causes of VPCs include the following:

  • Acute myocardial infarction

  • Valvular heart disease, especially mitral valve prolapse

  • Cardiomyopathy (eg, ischemic, dilated, hypertrophic, infiltrative) [2]

  • Myocardial stretch

  • Cardiac contusion

  • Bradycardia

  • Tachycardia (high-catecholamine state)

Noncardiac causes of VPCs include the following:

  • Electrolyte disturbances (hypokalemia, hypomagnesemia, or hypercalcemia)

  • Medications (eg, digoxin, tricyclic antidepressants, aminophylline, amitriptyline, pseudoephedrine, fluoxetine)

  • Other drugs (eg, cocaine, amphetamines, caffeine, alcohol)

  • Anesthetics

  • Surgery

  • Infection

  • Stress

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!