How is N-terminal proBNP (NT-proBNP) testing used in the evaluation of cardiogenic pulmonary edema (CPE)?

Updated: Jul 23, 2020
  • Author: Ali A Sovari, MD, FACP, FACC; Chief Editor: Gyanendra K Sharma, MD, FACC, FASE  more...
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Answer

Ventricular myocytes secrete proBNP in response to muscle-wall tension. NT-proBNP has a longer half-life (120 min) than that of BNP (20 min). Although NT-proBNP is less studied than BNP, its levels are well correlated with BNP levels.

The cutoff value for NT-proBNP of greater than 450 pg/mL in patients younger than 50 years correlates to BNP values of greater than 100 pg/mL. NT-proBNP is less accurate than BNP in patients older than 65 years.


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