What are the indications for thrombolytic therapy in the treatment of cor pulmonale?

Updated: Dec 15, 2017
  • Author: Derek Leong, MD; Chief Editor: Henry H Ooi, MD, MRCPI  more...
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Thrombolytic therapy is indicated in patients with acute cor pulmonale due to a pulmonary embolism resulting in hemodynamic instability. In some cases, thrombolytic therapy may be indicated in patients with severe RV dysfunction without resultant hypotension to prevent further decompensation. [43] Thrombolytic agents, including tissue plasminogen activator (tPA), result in accelerated lysis of clots and can be administered systemically or via a catheter. As always, the risk of bleeding must be a strong consideration when using thrombolytic therapy.

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