What are the negligible risk criteria for postexposure prophylaxis (PEP) following nonoccupational HIV infection exposure?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Negligible risk criteria include the following:

  • Site of exposure - Vagina, rectum, eye, mouth, or other mucous membrane, intact or nonintact skin, or percutaneous contact

  • Infectious material - Urine, nasal secretions, saliva, sweat, or tears if not visibly contaminated with blood

  • Source status - Regardless of the known or suspected HIV status of the source

Postexposure prophylaxis is not recommended in patients who present more than 72 hours after exposure or who have exposures deemed to represent a negligible risk. If antiretroviral therapy is initiated, it should be continued for 28 days. [116]

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