What are the DHHS guidelines for postexposure prophylaxis (PEP) antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Postexposure prophylaxis (PEP) has been demonstrated to reduce the risk of HIV infection when administered soon after exposure. Guidelines are available for occupational and nonoccupational exposures. [115, 116] Treatment recommendations are similar, however, due to an effort to reduce confusion and increase adherence by providing better tolerated antiretroviral regimens. In both situations, patients taking PEP should be counseled on the importance of adherence for the duration of treatment. 

If the source patient’s identify is known and able to be interviewed, providers should attempt to elicit current antiretroviral treatment, most recent HIV viral load, and history of resistance to avoid using potentially ineffective agents as part of the PEP regimen. However, soliciting this information should not delay the initiation of PEP; the regimen can be altered at a later time if needed.

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