Which protease inhibitors are used in antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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HIV protease inhibitors (PIs) were first introduced in 1995 and are an integral part of treatment of HIV infection. [8] A total of 8 compounds are approved for use, as follows:

Although all protease inhibitors exhibit the same mechanism of action, they have important differences in pharmacokinetics, efficacy, and adverse event profiles.

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