What is the role of nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in the antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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The nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) were the first agents available for the treatment of HIV Infection. Although less potent against HIV than non-nucleoside reverse transcriptase inhibitors (NNRTIs),  protease inhibitors (PIs), and integrase strand-transfer inhibitors (INSTIs), the NRTIs have had a central role in antiretroviral treatment and remain part of the current standard of care. [7, 8] They exhibit activity against HIV-1 and HIV-2. [9]

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