What are the saquinavir (Invirase) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Saquinavir (Invirase):

  • Dosage forms: 500-mg tablet; 200-mg hard gelatin capsule
  • Adult dose: 1000 mg + ritonavir 100 mg PO bid
  • Comments: Unboosted saquinavir is not recommended; take with food, or within 2 h pc
  • Adverse events: Nausea, diarrhea, headache, hyperlipidemia, hyperglycemia, PR and QT interval prolongation

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