What is used as secondary prophylaxis against Candida infection in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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For mucocutaneous and esophageal Candida infection, long-term suppressive therapy is usually not indicated or necessary, especially if the CD4 count rises above 200 cells/μL (BIII recommendation). Frequent or long-term therapy can result in resistance. If the decision is made to use suppressive therapy, use fluconazole 100 mg orally daily or 3 times weekly for oropharyngeal disease (BI recommendation), fluconazole 100 mg to 200 mg orally daily for esophageal disease (BI recommendation), or fluconazole 150 mg orally weekly for vulvovaginal disease (BII recommendation).

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