What is used as secondary prophylaxis against cryptococcal meningitis in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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For cryptococcal meningitis, after initial liposomal amphotericin and flucytosine therapy for at least 2 weeks, give fluconazole 400 mg orally or intravenously daily as "consolidation" therapy (AI recommendation). This should be followed by "maintenance" therapy with fluconazole 200 mg PO daily for at least 1 year (AI recommendation) and until the CD4 count exceeds 100 cells/μL for 3 months (BII recommendation).

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