What is used as secondary prophylaxis against M avium complex (MAC) infection in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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For M avium complex (MAC) infection, the following is recommended: clarithromycin 500 mg orally twice daily plus ethambutol 15 mg/kg orally daily with or without rifabutin 300 mg orally daily for 12 months until patients have no signs or symptoms of MAC disease and until the CD4 count is greater than 100 cells/μL for 6 months (AII recommendation).

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