What is secondary prophylaxis (maintenance therapy) for the prevention of relapse of opportunistic infections in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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Secondary prophylaxis (called maintenance therapy in the NIH/CDC guidelines) consists of therapy given to prevent relapse of known and appropriately treated OI that have occurred before effective antiretroviral therapy (ART). For most of these infections, the initial treatment is much more intensive and may last for 2 to 4 weeks, followed by the secondary prophylaxis regimen. This is particularly noteworthy for cryptococcal meningitis, which must be treated initially with amphotericin and flucytosine.

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