What is the role of prophylaxis against viral infections in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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Recurrent genital and, occasionally, oral herpes simplex infections, zoster, molluscum contagiosum, and human papillomavirusinfections are common. Primary infections are best avoided. Recurrent herpes simplex and zoster may be prevented with acyclovir 400 mg twice daily, continued indefinitely (AI recommendation). The efficacy of the 9-valent recombinant human papillomavirus (HPV) vaccine to prevent warts and neoplasia is unknown in adult patients infected with HIV, but it is recommended for men and women aged 11-26 years and ages 27-45 with shared decision making. [24]  Progressive multifocal leukoencephalopathy (JC virus) is not susceptible to prophylaxis, and no therapy other than immuno-reconstitution is recommended. HHV-8 infection is not specifically treated, but HIV viral therapy plus chemotherapy is given for Kaposi sarcoma.

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