What is the primary prophylaxis against P carinii pneumonia (PCP) in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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Indications for PCP prophylaxis include a CD4 count of fewer than 200 cells/μL (AI recommendation) or less than 14% of lymphocytes (BII recommendation). The preferred regimen is trimethoprim-sulfamethoxazole 1 double-strength tablet orally daily (AI) or 1 double-strength tablet orally 3 times weekly(BI). Alternatives include dapsone 100 mg orally daily (BI), aerosolized pentamidine 300 mg administered via the Respirgard II nebulizer monthly (BI), or atovaquone suspension 750 mg (5 mL) orally twice daily)(BI). [1]

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