What is the role of vaccines in the prevention of opportunistic infections in patients with HIV infection?

Updated: Mar 09, 2021
  • Author: Justin R Hofmann, MD; Chief Editor: John Bartlett, MD  more...
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Pneumococcal PCV13 vaccine should be administered on the first visit, and on subsequent visits, vaccines for hepatitis Ahepatitis B, diphtheria-tetanus, and influenza should be administered as indicated by serology results, history, and season, respectively. Patients should be given the PPV23 vaccine at least 8 weeks after the PCV13, if it has not already been administered. [1]  The 9-valent recombinant HPV vaccine should be given to all patients 11 to 26 years of age, or up to 45 years of age with shared decision making. [1]  All live vaccines should be avoided in HIV-infected patients, with the exception of measles and varicella vaccines in immunocompetent patients (in general, CD4 count >200 cells/μL). [1]  The meningococcal ACWY vaccine should be administered routinely. [1]  Meningococcal B vaccine may be given to adolescents and young adults based on individual clinical decision. [1]  Haemophilus influenzae B vaccine should be administered to adults and adolescents with HIV for such indications as asplenia, hematopoietic stem cell transplant, and others. [1]  

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