Which medications in the drug class Calcium channel blockers are used in the treatment of Aortic Regurgitation?

Updated: Nov 19, 2018
  • Author: Stanley S Wang, JD, MD, MPH; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Calcium channel blockers

Calcium channel blockers inhibit the movement of calcium ions across the cell membrane, depressing impulse formation (automaticity) and conduction velocity.

Nifedipine (Procardia, Adalat, Nifedical)

Produces significant fall in arterial pressure, reduces LV volume and mass, increases EF, and delays need for AVR in asymptomatic patients with severe AR and normal LV systolic function. Effective vasodilator therapy requires adjustment of dosage to decrease arterial pressure.

Diltiazem (Cardizem, Dilacor, Cartia XT, Tiazac)

During depolarization, diltiazem inhibits calcium ions from entering slow channels and voltage-sensitive areas of vascular smooth muscle and myocardium. It produces vasodilation but causes less reflex tachycardia than nifedipine does. Diltiazem may be useful if patients develop excessive hypotension with nifedipine.

Amlodipine (Norvasc)

Amlodipine has a longer duration of action than nifedipine or diltiazem and requires less frequent dosing. Experience with this agent in pulmonary hypertension is not as extensive as that with other agents. Amlodipine has fewer effects on conduction and infrequently causes atrioventricular (AV) block.


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