Which medications in the drug class Diuretics are used in the treatment of Aortic Regurgitation?

Updated: Nov 19, 2018
  • Author: Stanley S Wang, JD, MD, MPH; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Diuretics

Diuretics increase urine flow. These agents are ion-transport inhibitors that decrease the reabsorption of sodium at different sites in the nephron. Diuretics have major clinical uses in managing disorders involving abnormal fluid retention (edema) or in treating hypertension, in which their diuretic action causes decreased blood volume.

Furosemide (Lasix)

Like torsemide and bumetanide, furosemide is a potent loop diuretic. Compared with all other classes of diuretics, loop diuretics have the highest efficacy in mobilizing sodium and chloride from the body, inhibiting the Na+, K+, and Cl- cotransport in the ascending limb of the loop of Henle.

Furosemide and other loop diuretics are indicated in the treatment of edema associated with CHF, cirrhosis of the liver, and renal disease, including nephrotic syndrome. They may be used alone or with other antihypertensive agents to treat hypertension.

Bumetanide

Bumetanide increases the excretion of water by interfering with the chloride-binding cotransport system, which, in turn, inhibits sodium and chloride reabsorption in the ascending loop of Henle. This agent does not appear to act in the distal renal tubule.


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