Which medications are indicated in the treatment of aortic regurgitation (AR)?

Updated: Nov 19, 2018
  • Author: Stanley S Wang, JD, MD, MPH; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Vasodilator therapy may be considered under the previously described conditions. Many classes of vasodilators have been studied, with long-term hydralazine or nifedipine therapy being associated with higher EF and less LV dilation in smaller trials. Results with enalapril and quinapril have been less consistent. [4]

Historically, beta-blocker therapy has been discouraged in patients with severe AR because heart rate reduction could prolong diastole, thus worsening AR. However, beta-blockers have been shown to produce beneficial neuroendocrine alterations in patients with heart failure. An observational study suggested that beta-blocker therapy is associated with a significant survival benefit in patients with severe AR, [44] spurring hope that further investigation will confirm this finding and allow its translation into a clinically meaningful recommendation.


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