What is microthrombosis and how is it managed in heparin-induced thrombocytopenia (HIT)?

Updated: Sep 10, 2021
  • Author: Sancar Eke, MD, FASN; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Warfarin may cause microthrombosis in patients with HIT. These patients typically present with an international normalized ratio (INR) greater than 4, which corresponds to severe protein C depletion. Initiation of warfarin should be postponed until substantial platelet recovery. Preferably, warfarin should not started before the platelet count exceeds 150 x 109/L. [2, 60] If warfarin has already been started, vitamin K should be given. [48]

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