What are the acute signs and symptoms of heparin-induced thrombocytopenia (HIT)?

Updated: Sep 10, 2021
  • Author: Sancar Eke, MD, FASN; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Acute systemic reactions include chills, fever, dyspnea, chest pain, and flushing. [40] Patients with HIT can also present with deep venous thrombosis (DVT) or pulmonary embolism. In patients with DVT who are started on warfarin, severe protein C depletion can develop, leading to warfarin-induced venous limb gangrene and likely loss of the limb. [41] Less often, patients may present with arterial thromboembolism (eg, stroke, myocardial infarction).

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