How does the prevalence of heparin-induced thrombocytopenia (HIT) vary by sex?

Updated: Sep 10, 2021
  • Author: Sancar Eke, MD, FASN; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Men have significantly less risk than women for thrombotic manifestations in HIT. Women diagnosed with HIT and thrombosis are 1.7 times more likely than men to have a new HIT-associated thrombotic event. [31]

The higher frequency of HIT in females was found most strikingly in patients treated with UHF. There was no relationship between sex and the risk for HIT in patients treated with low molecular weight heparin (LMWH). [32] LMWH in prevention of HIT may have the greatest absolute benefit in females undergoing surgical thromboprophylaxis. [32]

In a retrospective study of 408 patients diagnosed with HIT, 66% of patients were older than 60 years. [35]  Obeng and colleagues, in a retrospective cohort study of 155 patients under 21 years old with sufficient data for 4Ts scoring for HIT, found that the prevalence of HIT was significantly lower in these patients than in adults.

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