What are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)?

Updated: Oct 07, 2019
  • Author: Guy J Petruzzelli, MD, PhD, MBA, FACS; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Basal cell carcinoma and squamous cell carcinoma

BCCs and SCCs make up the majority of nonmelanoma malignant skin cancers. BCCs are the most common malignant neoplasm. Although they are usually locally invasive, they have been observed to metastasize on rare occasions. The most common primary site of metastatic BCC is the scrotum, where the rate of metastatic disease is 12%. Primary lesions affecting the head and neck can also be a predisposing factor for metastasis, but this is less common.

SCCs are malignant neoplasms arising from transformed keratinocytes. They have rare metastatic potential, but in immunocompromised patients, SCCs are more aggressive and prone to metastasis.

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