Which form of vitamin D supplementation decreased mortality in elderly women with vitamin D deficiency, and what is the relation of vitamin D supplementation to cancer risk?

Updated: Dec 15, 2020
  • Author: Vin Tangpricha, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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A Cochrane Review of 50 randomized, controlled trials that included more than 94,000 individuals, primarily elderly women, found that vitamin D3 supplementation decreased mortality. Other forms of vitamin D, including vitamin D2, calcitriol, and alpha-calcidiol, did not reduce mortality. [67]

A study by Manson et al to evaluate the efficacy of vitamin D supplementation and omega-3 fatty acids in lowering the risk of invasive cancer and cardiovascular disease found no such reduction associated with the administration of vitamin D. The report, which included 25,871 participants (males aged 50 years or older and females aged 55 years or older) and had a median follow-up period of 5.3 years, determined that compared with a placebo group, there was no decrease in the incidence of breast, prostate, or colorectal cancer, or in myocardial infarction, stroke, or cardiovascular-related death, among subjects who consumed 2000 IU per day in supplementary vitamin D. [68]

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