What is the role of vitamin D therapy in the treatment of organ transplantation-related osteoporosis?

Updated: Jul 02, 2020
  • Author: Carmel M Fratianni, MD, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

Administer vitamin D at 400-1000 IU/d to all patients. However, patients with malabsorption, cystic fibrosis, or PBC have higher vitamin D requirements, [12, 91] and 25-hydroxyvitamin D levels should be monitored to assess the adequacy of replacement.

Parent vitamin D at doses of 400-1000 IU daily is insufficient to prevent posttransplant osteoporosis. Active metabolites of vitamin D are more promising in this regard and may work by improving intestinal calcium absorption and directly or indirectly suppressing PTH secretion. [92]


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