What are risks associated with the use of glyburide for the management of gestational diabetes mellitus (GDM)?

Updated: Apr 29, 2020
  • Author: Thomas R Moore, MD; Chief Editor: George T Griffing, MD  more...
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Glyburide should not be used in the first trimester, because its effects, if any, on the embryo are unknown. Research in this area, although needed, has been difficult given the known teratogenic effects of first-generation sulfonylurea, which readily crossed the placenta.

Glyburide has been shown to be safe in breastfeeding, with no transfer into human milk.

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