What is the role of supplementation in dietary therapy for gestational diabetes mellitus (GDM)?

Updated: Apr 29, 2020
  • Author: Thomas R Moore, MD; Chief Editor: George T Griffing, MD  more...
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According to a randomized, placebo-controlled study of pregnant women with gestational diabetes mellitus, supplemental calcium plus vitamin D at 24-28 weeks' gestation may have beneficial effects on metabolic profile. Researchers found that women treated with 1000 mg calcium per day for six weeks and 50,000 U vitamin D3 at baseline and on day 21 of the 6-week intervention showed significant improvements in fasting plasma glucose, serum insulin levels, serum low-density lipoprotein cholesterol levels, and high-density lipoprotein cholesterol levels. [72, 73]

In a study of 76 pregnant women with gestational diabetes mellitus, Yazdchi et al found that vitamin D3 supplementation starting at 24-28 weeks’ gestation decreased fasting blood glucose and HbA1C levels but had no significant impact on patients’ lipid profiles or high-sensitivity C-reactive protein values. [74]

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