What is the role of GH replacement in GH deficiency due to hypopituitarism?

Updated: Apr 14, 2020
  • Author: Angela Gentili, MD; Chief Editor: George T Griffing, MD  more...
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According to a 2011 systematic review, GH replacement [21] is effective in reversing some of the changes that occur in older adults (aged >60 y) with GH deficiency secondary to hypopituitarism. The effects of GH replacement in these patients include the following:

  • Decreased waist circumference (by about 3 cm) and waist-to-hip ratio without changing BMI; GH increased lean body mass and decreased total fat mass in 4 studies but not in another 2

  • Reduction in total cholesterol level by 4-8% and low-density lipoprotein cholesterol (LDL) by 11-16% but no change in HDL and triglycerides

  • Improvement in quality of life

  • No consistent improvement in blood pressure or bone mineral density; additionally, no data are available on GH-deficient patients older than 80 years

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