How does the decline with aging of growth hormone (GH) secretion differ between males and females?

Updated: Apr 14, 2020
  • Author: Angela Gentili, MD; Chief Editor: George T Griffing, MD  more...
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Several studies have shown that the amplitude of GH pulses is reduced with aging both in men and women. [17] In aging men, GH secretion declines by 50% every 7 years after age 18-25 years. [1] The negative effect of age on 24-hour mean serum GH is twice as much in men as in premenopausal women. Estrogens may have a protective effect that limits the rate of decline of GH secretion with aging.

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