Why are triglyceride levels elevated in patients with uncontrolled type 2 diabetes mellitus and hyperinsulinemia?

Updated: Jul 23, 2021
  • Author: Mary Ellen T Sweeney, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

In patients with uncontrolled type 2 diabetes mellitus and hyperinsulinemia, triglycerides are elevated for several reasons, including the following:

  • Lipoprotein lipase is less effective in the insulin-resistant state

  • Overproduction of VLDL by the liver is common in patients with diabetes who are often overweight

  • Diabetes mellitus is one of the conditions that leads to incomplete metabolism of VLDL, causing increased remnant VLDL or IDL observed in dysbetalipoproteinemia (see Dysbetalipoproteinemia).


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