How is hypertriglyceridemia (high triglyceride levels) defined by the Fredrickson classification?

Updated: Jul 23, 2021
  • Author: Mary Ellen T Sweeney, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Hyperlipidemia has been defined by the Fredrickson classification, which is based on beta-quantification, a process involving ultracentrifugation followed by electrophoresis. [3] In this system, shown in Table 1, below, all categories except type IIa are forms of hypertriglyceridemia.

Table 1. Fredrickson Classification of Hyperlipidemia (Open Table in a new window)

Type

Serum Elevation

Lipoprotein Elevation

I

Cholesterol and triglycerides

Chylomicrons

IIa

Cholesterol

LDL

IIb

Cholesterol and triglycerides

LDL, VLDL

III

Cholesterol and triglycerides

IDL

IV

Triglycerides

VLDL

V

Cholesterol and triglycerides

VLDL, chylomicrons

IDL = intermediate-density lipoprotein; LDL = low-density lipoprotein; VLDL = very low-density lipoprotein.

Source:  Fredrickson DS, Lees RS. A system for phenotyping hyperlipidaemia. Circulation. Mar 1965;31:321-7. [3]


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